2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-117822
    BRD0209 1597439-87-6 99.63%
    BRD0209 is a potent, selective and dual inhibitor of GSK3α/β inhibitor (GSK3α IC50 = 19 nM; GSK3β IC50 = 5 nM). BRD0209 is also a reversible ATP-competitive inhibitor with fast-off kinetics (Ki = 4.2 nM, respectively). BRD0209 is a tricyclic pyrazolotetrahydroquinolinone compound. BRD0209 has the potential for the research of mood disorder diseases.
    BRD0209
  • HY-118840
    1,4-D-Gulonolactone 6322-07-2 99.56%
    1,4-D-Gulonolactone is an endogenous metabolite.
    1,4-D-Gulonolactone
  • HY-119443
    Neridronate 79778-41-9 ≥98.0%
    Neridronate is an aminobisphosphonate. Neridronate induces osteoblast differentiation, enhances alkaline phosphatase activity and mineralized nodule formation. Neridronate inhibits endothelial cell proliferation, fibroblast growth factor-2-induced capillary-like tube formation, and angiogenesis. Neridronate can be used for osteogenesis imperfecta and Paget’s disease of bone.
    Neridronate
  • HY-120160
    Darglitazone 141200-24-0 99.19%
    Darglitazone (CP-86325), a thiazolidinedione, is a potent, selective, and orally active PPAR-γ agonist. Darglitazone is effective in controlling blood glucose and lipid metabolism, and can be used for type II diabetes research.
    Darglitazone
  • HY-120215
    KT203 1402612-64-9 ≥98.0%
    KT203 is a potent and selective inhibitor of α/β-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.31 nM in Neuro2A cells.
    KT203
  • HY-124418
    SBI-477 781628-99-7 98.0%
    SBI-477 is a chemical probe that stimulates insulin signaling by deactivating the transcription factor MondoA. SBI-477 can lead to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4). SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes.
    SBI-477
  • HY-124689
    TR-100 1128165-86-5 ≥99.0%
    TR-100 is a small molecule inhibitor of tumor-associated troponin (Tpm). TR-100 affects the interaction of Tpm3.1 with actin filaments by binding to the C-terminal of Tpm3.1, thereby affecting the stability and function of the actin filaments. This mechanism of action allows TR-100 to specifically affect actin filaments in cancer cells without compromising heart muscle function. TR-100 can be used to study the role of Tpm3.1 in cancer cell proliferation and survival and the effects of Tpm3.1 on insulin-stimulated glucose uptake and insulin secretion.
    TR-100
  • HY-125138
    ω-Muricholic Acid 6830-03-1 ≥99.0%
    ω-Muricholic Acid is a bile acid. ω-Muricholic Acid is a metabolite of chenodeoxycholic acid in jaundiced mice. ω-Muricholic Acid can be used for the research of surgically jaundiced.
    ω-Muricholic Acid
  • HY-125643
    Pitavastatin lactone 141750-63-2 98.74%
    Pitavastatin lactone is a major metabolite of Pitavastatin (HY-B0144A) in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase.
    Pitavastatin lactone
  • HY-127035
    Tristearin 555-43-1 ≥98.0%
    Tristearin (Glycerol tristearate) is a triglyceride derived from three units of stearic acid.
    Tristearin
  • HY-128421
    Tridecanedioic acid 505-52-2
    Tridecanedioic acid is an endogenous metabolite. Tridecanedioic acid is an endogenous metabolite. Tridecanedioic acid is related to the metabolic regulation of non-alcoholic fatty liver disease (NASH) and may be an important node molecule in the intestinal microbiota-host metabolism interaction network. Tridecanedioic acid is significantly accumulated in tolerant cabbage-type rapeseed varieties and has a lower content in sensitive varieties. It plays an important role in the defense response against the infection of the small cabbage moth (Plutella xylostella). Tridecanedioic acid can be used as a biomarker for plant insect resistance or a diagnostic marker for metabolic diseases.
    Tridecanedioic acid
  • HY-128447
    Allyl methyl sulfide 10152-76-8 98.0%
    Allyl methyl sulfide is an orally active organic sulfide. Allyl methyl sulfide is one of the main active ingredients in garlic volatile metabolites. Allyl methyl sulfide can be extracted from garlic. Allyl methyl sulfide enhances SOD activity, inhibits NF-κB signaling pathway, and upregulates pancreatic GLUT2 expression. Allyl methyl sulfide has significant antioxidant, anti-inflammatory and hypoglycemic activities. Allyl methyl sulfide can be used in the research of diabetes and its complications.
    Allyl methyl sulfide
  • HY-129143
    Delphinidin-3-sambubioside chloride 53158-73-9
    Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L..
    Delphinidin-3-sambubioside chloride
  • HY-133108
    Azadirachtin B 106500-25-8 99.17%
    Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties.
    Azadirachtin B
  • HY-136975
    Caspase-3-IN-1 872254-32-5
    Caspase-3-IN-1 (compound 11b) is a potent Caspase-3 inhibitor, with an IC50 of 14.5 nM.
    Caspase-3-IN-1
  • HY-138119
    γ-Glutamylserine 5875-35-4 99.95%
    γ-Glutamylserine (γ-Glu-Ser) is a calcium receptor activator. γ-Glutamylserine can be used for Parkinson's disease research, as well as diabetes or obesity study.
    γ-Glutamylserine
  • HY-139170
    CAY10746 2247240-76-0 98.61%
    CAY10746 is a selective Rho kinase (ROCK) inhibitor. CAY10746 has inhibitory activity for ROCK I, ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively. CAY10746 can be used for the research of diabetic retinopathy (DR).
    CAY10746
  • HY-139381
    MitoEbselen-2 chloride 1638973-78-0
    MitoEbselen-2 chloride (MitoPeroxidase 2), a mitochondria-targeted mimic of glutathione peroxidase, is a radiation mitigator. MitoEbselen-2 chloride is effective in reducing lipid hydroperoxides, preventing apoptotic cell death.
    MitoEbselen-2 chloride
  • HY-141668
    BCAT-IN-1 1875078-61-7 98.06%
    BCAT-IN-1 is a potent, selective and orally active inhibitor of BCATm, with a pIC50 of 7.3. BCAT-IN-1 shows 100-fold selectivity for BCATm over BCATc (pIC50=5.4). BCAT-IN-1 can be used for the research of metabolic diseases.
    BCAT-IN-1
  • HY-142069
    KB-R7785 168158-16-5 99.90%
    KB-R7785 is a matrix metalloproteinase (MMP) inhibitor, which improves insulin sensitivity by inhibiting TNF-α production. KB-R7785 can be used for diabetes research. KB-R7785 has a protective efficacy against focal cerebral ischemia.
    KB-R7785
Cat. No. Product Name / Synonyms Application Reactivity